Rapid response to lipids profile and leukocyte gene expression after rosuvastatin administration...

HUA Cong-xiao, LI Yi-shi, LIU Yu-qing, LIU Hong, LI Na, WU Ying, XU Li, HUANG Yi-ling Background Statins are potent lipid-lowering agents widely used in medical practice. There has been growing evidence suggesting the pleiotropic effects of statins in addition to the lipid-lowering effect. However, it is still unclear how rapidly the beneficial effects of statins occur. The transcriptome of peripheral blood cells can be used as a sensor to drug therapy. The purpose of the study was to investigate the acute effects of rosuvastatin both on lipids profile and gene expression of peripheral leukocytes following therapy with a single dose of rosuvastatin. Methods Thirty healthy Chinese male volunteers were enrolled. The serum lipids, high-sensitivity C-reactive protein, and plasma fibrinogen were determined before and 72 hours... [read full story]