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Researchers have identified a protein released by dying brain tumor cells that provides an effective way to gauge the effectiveness of a novel gene therapy treatment for brain cancer. The finding paves the way for a Phase 1 clinical trial expected to begin in late 2009. The two-pronged gene therapy was devised by scientists at the Cedars-Sinai Board of Governors Gene Therapeutics Research Institute. It uses a harmless, genetically engineered virus to deliver a combination of proteins and a drug to kill tumor cells, which triggers an ongoing immune response, thus preventing the development of recurrent malignant brain tumor cells. The Cedars-Sinai team, led by Pedro R. Lowenstein, M.D., Ph.D., director of the Board of Governors Gene Therapeutics Research Institute, and Maria G. Castro, Ph.D., co-director of the Institute,... [read full story]                    

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